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KMID : 1138520220250010052
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Journal of Pharmacopuncture
2022 Volume.25 No. 1 p.52 ~ p.62
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Qualitative Analysis of Proteins in Two Snake Venoms, Gloydius Blomhoffii and Agkistrodon Acutus
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Ha Su-Jeong
Choi Yeo-Ok
Kwag Eun-Bin
Kim Soo-Dam
Yoo Hwa-Seung
Kang In-Cheol
Park So-Jung
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Abstract
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Objectives: Snake venom is a complex mixture of various pharmacologically active substances, such as small proteins, peptides, and organic and mineral components. This paper aims to identify and analyse the proteins in common venomous snakes, such as Gloydius blomhoffii (G. blomhoffii) and Agkistrodon acutus (A. acutus), in Korea.
Methods: We used mass spectrometry, electrophoresis, N-terminal sequencing and in-gel digestion to analyse the proteins in these two snake venoms.
Results: We identified eight proteins in G. blomhoffii venom and four proteins in A. acutus venom. The proteins detected in G. blomhoffii and A. acutus venoms were phospholipase A2, snake venom metalloproteinase and cysteine-rich secretory protein. Snake C-type lectin (snaclec) was unique to A. acutus venom.
Conclusion: These data will contribute to the current knowledge of proteins present in the venoms of viper snakes and provide useful information for investigating their therapeutic potential.
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KEYWORD
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gloydius blomhoffii, agkistrodon acutus, proteomics, venomics, venom proteome
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